Spero was a large man with dark hair, a dark complexion and was good looking in a rough way" Philip Carlo wrote. "He was fair, smart, and exceedingly well versed in the ways of the street". According to the testimony of boss-turned-informant Joseph Massino, Anthony Spero was inducted into the Bonanno crime family by Underboss Carmine Galante on June 14, 1977. The ceremony was held in a Queens bar, and among those inducted were Massino, Joseph Chilli Jr., and several other men.
A reserved and low profile man, Spero's hobby was breeding racing pigeons in coops on the roof of a Bensonhurst building, a hobby he shared with Capo Dominick Napolitano. To avoid electronic surveillance from law enforcement, Spero sometimes held crew meetings on the same rooftop. Spero was married with two daughters, Jill and Diana, and owned a home in Staten Island.
One of Spero's most lucrative enterprises was selling stolen fireworks. He owned huge warehouses of fireworks and made close to $5 million a year selling them. Every Fourth of July, Spero would stage a fireworks display on Bath Avenue in Bath Beach, Brooklyn that allegedly cost him several hundred thousand dollars. For these parties, Spero also supplied food that was said to be enough to feed all of Bensonhurst, Brooklyn." Spero was a close associate of Colombo crime family capo Gregory Scarpa and Lucchese crime family capo and future underboss Anthony Casso they were all connected to the hobby of pigeon racing. Following the death of Alphonse Indelicato and his son Anthony Indelicato, Bonanno mobster Thomas Pitera became close to Spero. Spero later inducted Pitera into the Bonanno crime family at an initiation ceremony at the house of Bonanno capo Frank Lino.
Spero was also very close with Bonanno made soldier Peter Monteleone Him and Pete would sell a large amount of fireworks every Fourth of July together.
In 1990, Spero ordered the murder of Louis Tuzzio, a Bonanno associate who had botched a mob killing. An ambitious gangster, Tuzzio had offended Spero by demanding to become a made man. In January 1990, Tuzzio was found dead in his brother Nicky's Chevrolet Camaro in Brooklyn with numerous bullet wounds in the back of the head. John Gotti also pressured Spero to kill him for wounding one of his skippers son's when that piece of work was done on Gussie right in front of Louis Tuzzio's moms apt.
In 1991, Spero ordered the murder of Vincent Bickelman, a burglar from Brooklyn. In August 1991, Bickelman had broken into the home of Spero's daughter Jill and stolen her jewelry and a fur coat. On September 15, 1991, Bickelmen's body, with six bullet wounds, was discovered near his apartment in Bath Beach. Bickelman was allegedly murdered by Gambino associate Paul Gulino, an ambitious young mobster who ran the Bath Street Crew.
In 1993, Spero ordered Gulino's murder. In July of that year, during an argument with Spero at the Bath Beach social club, Gulino made physical contact with the capo, a breach of Cosa Nostra protocol. Two weeks later, Gulino's parents discovered him shot to death in their kitchen.
On January 24, 1994, Spero was indicted on federal racketeering charges of extortion and murder. The indictment stated that Spero controlled a business that used extortion to place "Joker Poker" gambling machines in bars, social clubs, and other establishments around the city. Spero was also charge with the 1991 murder of Marc Goldberg, a rival in the illegal gambling business. In April 1995, Spero was acquitted of the Goldberg murder, but convicted of extortion. He was sentenced to two years in prison. In 1997, Spero was released from prison.
On May 30, 1999, Spero was indicted on federal racketeering charges that included loansharking and the Tuzzio, Bickelman and Gulino murders from the 1990s. Spero pleaded not guilty on all the counts. Spero was released from jail and confined to his Staten Island house, wearing an electronic ankle bracelet. During the trial, one of the witnesses testifying against Spero was Alphonse D' Arco, the former underboss of the Lucchese crime family. D'Arco recounted a 1991 conversation in which Spero stated that family members of mob informants, including women and children, should be murdered in retaliation. On April 5, 2001, Spero was convicted of the three murders and other racketeering charges. On April 16, 2002, Spero was sentenced to life in prison. His lawyer requested leniency due to Spero's poor health, but the judge denied the request.
On September 29, 2008, Spero died at age 79 at the Butner Federal Correctional Complex (FCC) in Butner, North Carolina. Spero's body was interred at the Cemetery of the Resurrection in Staten Island, New York.